HD-tDCS高精度经颅直流电刺激仪产品介绍

High Definition-transcranial Direct Current Stimulation

高精度经颅直流电刺激是一种使用微弱的直流电聚焦刺激大脑皮层组织的高精度刺激，不同于其他神经调节技术，HD-tDCS是一种无创的，操作简单的，安全，并且具有极高性价比的经颅直流电刺激技术。Soterix Medical是全球唯一的高精度经颅直流电刺激仪制造商。

  HD-tDCS介绍　—————————————————

SoterixMedical高精度经颅直流刺激（HD-tDCS）是一种非侵入性技术，其大脑区域是使用头皮上的电极阵列作为目标，与使用传统的海绵电极的传统tDCS相比，HD-tDCS采用我们独有的Soterix Medical“高精度”小型环形电极，允许电流通过头皮上的小电极进行安全的通过，HD-tDCS通过使用Soterix Medical Neurotargeting软件为用户提供灵活性来确定大脑目标，与每个HD-tDCS硬件系统完全集成。

Soterix Medical HD-tDCS的亮点

Discovery of 4x1 HD-tDCS montage. Datta et al. 2009

The only hardware validated for safe and tolerated stimulation in multi-center clinical trials.

Other technologies and devices marketed for “small electrode transcranial stimulation” are not endorsed by Soterix Medical and are counter-indicated for use with any Soterix Medical stimulator or software, including 4x1 HD-tDCS. Soterix Medical is committed to the advancement of rational non-invasive neuromodulation through application of the highest scientific and medical standards.

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Four things about HD-tDCS —————————————————

❶ 4×1 HD-tDCS

❸ Peak Neuromodulation

高清经颅直流电刺激（HD-tDCS）是在纽约市立大学开发的，它引入了4x1 HD-tDCS montage （Datta 2009）， 4x1 HD-tDCS　montage 通过对皮质结构进行精确定位，明确地改变了非侵入性神经调节的可能性， 通过4x1环形电极刺激，使得环型半径减小却增加焦点， Soterix Medical Neurotargeting软件使高精度设计变得快速和简单，但创新并没有停止，科学家继续证明4x1 HD-tDCS可以进行单焦点刺激，这意味着中心电极的极性将决定环下神经调节的方向（Villamar 2013），与传统的tDCS相反，传统的tDCS需要一个阳极和一个阴极始终产生双向调制（即使在使用额外的头电极时），因此，4x1 HD-tDCS不仅能够选择皮质脑区域作为目标，而且能够以设计的极性调节该大脑区域的兴奋性，而不必考虑返回反电极流动情况。

针对4x1HD-tDCS的关键问题是“什么时候需要？”这个问题没有简单的答案，但是认识到大多数传统的tDCS方法产生大于50％的脑电流（包括深度）是重要的大脑结构，并与传统的tDCS个人间解剖差异意味着高峰脑电场的位置将差异很大。因此，通过保证目标处的峰值脑电场和限制大脑电流流向有限的区域，4x1HD-tDCS

❷ 高精度电极

❹ 高精度电极位置、数量和精度

在先进的神经调节设计中，需要允许在头部任意放置HD电极的软件和硬件。 蒙太奇的精度至关重要，这就是为什么刺激软件和支持硬件必须为用户提供灵活性和精确控制的原因。

Device Features

Each Soterix Medical HD-tDCS feature was developed by our team of biomedical engineers consulting closely with leading clinical centers. Designed to simply set-up, provide intelligent warning of a fault condition, and allow for adjusting for patient comfort , these features facilitate reliable and tolerated HD-tDCS. The Soterix Medical SmartScan™ feature is central in all HD-tDCS and tDCS devices to allow reliable set-up and monitoring.

Provides a continuous visual indication of electrode quality before and during stimulation.

From pre-stimulation set-up, to during stimulation monitoring, to post-stimulation confirmation, the Soterix Medical SmartScan™ feature provides an intuitive and clear indication of electrode contact quality. Use the SmartScan™ during set-up to adjust electrodes and head-gear for optimal fit. During stimulation, SmartScan™ provides a constant indication of electrode quality and can be monitored during adjustments (e.g. addition of saline to drying electrodes). After stimulation, SmartScan™ confirms a successful trial. Because “resistance” is not meaningful for HD-tDCS, SmartScan™ was developed by Soterix Medical engineers to provide clinical investigators with a simple to read indication of contact quality.

Clearly indicates the actual current supplied at the moment.

What other devices promise, the Soterix Medical HD-tDCS delivers. The back-lit display can be monitored during stimulation ramp up and to confirm target current intensity is achieved.

Simple and intelligent sham waveforms.

An automatic stimulation sham feature that is engaged with a simple switch. Auto-sham automatically calculates and produces a sham waveform based on the indicated “real” waveform. For example, for a corresponding real waveform of 1.5 mA and 10 minutes, auto-sham will provide a ramp up/down to 1.5 mA at the start of stimulation, and again after 10 minutes, with the timer automatically adjusted such that the total run time is exactly matched to the real case. Based on the Soterix Medical OpenPanel™ design principle: with no complicated programming or hidden drop-down menus required.

Provides continues monitoring of conditions during HD-tDCS

An exclusive technology from the trusted leader in neuromodulation, Soterix Medical HD-monitor is an intelligent oversight system that provides continuous monitoring of current flow conditions and can engage automatic ramp-down should unusual performance be detected. HD-tDCS is the most advanced non-invasive neuromodulation system, providing tremendous flexibility to operators. HD-monitor provides a further level of automatic over-sight before, during, and after stimulation.

The only platform designed to allow channel upgrades.

No other multi-channel stimulation systems is engineering to allow for scalability. The exclusive SCALABLE features integrated into every MxN device allows operators to feel comfortable knowing they can begin HD-tDCS with the most economical option without losing future scalability.

HD devices designed to integrate with Soterix Medical Neurotargeting Software.

Multichannel stimulation devices are only as customizable as the software used to design montages. With independent current control at each electrode with MxN devices, device power and flexibility requires intelligent montage design software. Neurotargeting software is the exclusive Soterix Medical solution to montage design and our HD-tDCS stimulator integrates seamlessly. Clinicians and scientists trust Soterix Medical engineers to provide the modeling and software sophistication to fully leverage HD-tDCS.

Optimized for the 4x1 HD-tDCS montage.

The 4x1 HD-tDCS montage remains the more popular and validated montage for unidirectional targeted brain neuromodulation. Devices optimized for 4x1 are designed to allow simple and consistent set-up including in high throughput clinical trials. Simple to use and designed by the inventors of 4x1 HD-tDCS, do not be confused by copycats and compromise the integrity of your trial and safety of your subjects. Soterix Medical Inc. (SMI) 4x1 certification is indicated on all validated 4x1 devices. *All MxN devices can provide 4x1 stimulation in addition to arbitrary configurations.

May be used to supply a very weak current prior to tDCS to help condition the skin.

Tickle™ may be used to both condition skin prior to tDCS or for naïve subject anxious about stimulation. A custom on-off waveform pattern generates mild and brief sensation under electrodes.

Allows the clinician to use a simple sliding bar to transiently decrease the current from the pre-set value, for example, based on subject feedback.

Based on feedback from leading clinical centers, Soterix Medical developed the exclusive feature Relax™, which accommodates subjects who may be anxious when stimulation is initiated or during the course of stimulation. The Relax™ slider may be adjusted from full to reduced intensity based on subject perception without interrupting or aborting stimulation.

With increased interest in the use of monitoring, such as EEG, PET, MEG, Eye-tracking, NIR and fMRI in conjunction with Soterix tDCS and HD-tDCS, Soterix Medical remains the only company with the technology and expertise to ensure successful integration. Stimulation generates artifacts in all monitoring modalities including fMRI (Antal A et. al 2012), such that use of technically compatible devices without also integrating rational trial design, can lead to errant findings.

Technology-informed integration of tDCS with monitoring technologies such as EEG, PET, MEG, NIR, fMRI, and eye tracking, is essential. tDCS⁺ is a free service to every Soterix Medical tDCS and HD-tDCS user. Soterix Medical tDCS⁺ leverages the experience of our clinical partners and our unmatched biomedical expertise, and is open to cross-platform compatibility so that you can use the monitoring technology you want and trust.

Soterix Medical biomedical engineers are available to discuss the combination of rational measurement with our industry standard Soterix tDCS and HD-tDCS, and only Soterix Neurotargeting allows co-registration of current flow and measured responses